The Khoka Project classifies coca (Erythroxylum spp.) into four major cultivated types, each tied to specific landscapes and traditions. Hayo (E. novogranatense var. novogranatense) was grown in pre-Columbian Colombia, especially in the Magdalena and Cauca valleys and the Sierra Nevada region. Thupa coca (E. novogranatense var. truxillense), known for its large royal leaves, likely originated on Peru’s northern desert coast and spread into the Andes and the Inca world, remaining common from Ecuador to northern Chile. Mamox coca (E. coca var. coca), linked to Andean highlands and humid eastern slopes, was cultivated from eastern Ecuador to Bolivia and the Amazonian foothills. Ipadu (E. coca var. ipadu), native to the lowland Amazon, has long been central to daily and ritual life among Indigenous groups of Brazil, Colombia, and Peru. Across South America, coca has been used for millennia for spiritual, medicinal, and social purposes, each variety adapted to a distinct ecological zone and cultural tradition.